First follow-up phase by questionnaires occurred at 4, 8, 12, 18, 24, 30, and 36 months of age. A subgroup of 600 infants has been evaluated at age 36-48 months for neurodevelopmental impairment. In addition, with parental consent obtained at the 8-month screening, residual dried blood samples (punches) from Guthrie cards were harvested and analyzed for 5 panels of inflammatory and environmental chemical biomarkers.
: Heart Follow-Up
The aim of the second follow-up is to determine whether childhood health, particularly of cardio-metabolic risk, through age 8 years differs by infertility treatment exposure. Parents will receive annual questionnaires and be invited for clinical exams and saliva collection programs.